Client SurveyCape Town
   
      
  Hypertension  
   
   
     
  Direct Renin  
     
  The Renin-angiotensin-Aldosterone system (RAS) plays a paramount role in water homeostasis and electrolyte balance, and in the regulation of arterial pressure. Measurement of plasma Renin and Aldosterone is therefore considered a marker of the Renin-angiotensin-Aldosterone system activity. Measurement of total Renin (proRenin plus active Renin) or of proRenin are of lesser clinical interest.  
     
 
Increased Renin levels are found in   Lowered Renin levels are found in
Secondary aldosteronism (severe hypertension of renal origin). Direct Renin measurement helps in differentiation of primary from secondary hyperaldosteronism in conjunction with Aldosterone assay.   Primary aldosteronism. Direct Renin measurement helps in differentiation of primary from secondary hyperaldosteronism in conjunction with Aldosterone assay.
Addison's disease   Salt-retaining steroid therapy
Low-sodium diet, administration of diuretics, hemorrhage   Renal artery stenosis
Chronic renal failure   Vasopressin (ADH) therapy
Salt-losing status because of gastrointestinal disease   Congenital adrenal hyperplasia with 17-hydroxylase deficiency
Renin-producing kidney tumors    
Essential hypertension    
Hypokalaemia    
Bartter's syndrome (high Renin levels without hypertension)    
 
     
  DiaSorin Liaison Direct Renin  
 
  • Direct, two site, sandwich type immunoluminometric assay using directly coated magnetic particles
  • Sample matrix: EDTA plasma
  • Sample volume: 200 µl
  • Incubation time: 30 min
  • Measuring range: 1.0 – 500 µIU/ml
  • Detection Limit: 1.0 µUI/ml
  
 
Product code Product name Method Kit Size Sample Type
310470 Liaison Direct Renin Direct, two site, sandwich immunoluminometric 100 test kit EDTA plasma
CA1533
CA1553 		GammaCoat Plasma Renin Activity RIA Coated Tubes 100 Tubes
500 Tubes 		EDTA Plasma
P2721 RENCTK (Plasma Renin) RIA Coated Tubes 100 Tubes EDTA Plasma
 
     
 
Back To Top      
  Aldosterone  
     
  Aldosterone is a mineral -retaining steroid, a hormone that directly regulates the retention of sodium by the kidneys and indirectly regulates the excretion of potassium. It plays an important role in the control of blood volume and blood pressure. Aldosterone is produced by the adrenal cortex. It usually takes a chain of events to stimulate the production of Aldosterone. The enzyme Renin is released by the kidneys when potassium is increased in the blood, sodium is decreased, there is a decrease in the volume of blood in circulation, low blood pressure, and/or when there is decreased blood flow to the kidneys. Renin splits angiotensinogen (a protein created by the liver) to form angiotensin I. Angiotensin-converting enzyme then acts on angiotensin I to form angiotensin II. Angiotensin II constricts blood vessels and stimulates the production of Aldosterone. In normal healthy people, when Renin increases Aldosterone increases; when Renin is low, Aldosterone decreases.  
     
 
Disorder Aldosterone Cortisol Renin
Primary hyperaldosteronism (Conn’s syndrome) High Normal Low
Secondary hyperaldosteronism High Normal High
Cushing’s syndrome Low-normal    
 
     
 
Product code Product name Method Kit Size Sample Type
P2714 ALDOCTK-2 (Aldosterone) RIA Coated Tubes 100 Tubes Serum, plasma, Urine
 
 
   
Back To Top      
 

LINKS

http://www.diasorin.com/

  
 
   
  Home | About us | Contact
Copyright © Humor Diagnostica