Client SurveyCape Town
   
      
  EBV  
   
   
     
  Epstein-Barr Virus (EBV) is a member of the herpes virus family and is the causative agent of infectious mononucleosis. Symptoms of infectious mononucleosis are sore throat, fever and swollen lymph nodes. In children the disease is often subclinical and indistinguishable from other mild disease of childhood; in adults, the illness lasts usually longer and is often associated with a prolonged fatigue syndrome. Heart problems and involvement of CNS occurs rarely and recovery usually occurs without treatment within 4 to 8 weeks from the infection. The clinical diagnosis is suggested on the basis of the symptoms along with the serological testing used to exclude other disease. In fact, EBV infection share the same symptoms with other agents like Toxoplasma gondii, adenovirus and CMV which cause much more severe disease especially if the infection occurs during pregnancy. The typical serological assays measure IgG and IgM antibodies directed against different components of EBV. Antigens derived from the Viral Capsid (VCA) are used to detect antibodies generally produced during the acute phase of the infection whereas the EBNA-1 protein is used to detect IgG produced during convalescence. IgG to the early antigen D (EA-D) appears in the acute phase and generally falls to undetectable levels after 3 to 6 months. In many people, detection of antibody to the early antigen is a sign of active infection, but in 20-30% of healthy individuals IgG to EA-D remain detectable for life. EA rises again if reactivation of infection occurs. It has also been demonstrated that IgM antibodies to VCA components of EBV tend to persist for several months after the infection in 5 to 10% of the cases. It is therefore important to provide the clinician a way to better define the stage of the infection. Parallel determination of VCA IgG, EBNA IgG and EBV IgM levels enables, through the use of a differential cutoff for the interpretation of EBNA IgG and EBV IgM results, better discrimination among different phases of EBV infection.  
 
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  DiaSorin Liaison EBV IgM  
 
  • 2-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, Plasma
  • Sample volume: 20 µl
  • Incubation time: 20 min
  • Measuring range: 0 – 160 U/ml
  
 
  DiaSorin Liaison VCA IgG  
 
  • 2-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, Plasma
  • Sample volume: 20 µl
  • Incubation time: 20 min
  • Measuring range: 0 – 750 U/ml
  
 
  DiaSorin Liaison EBNA IgG  
 
  • 2-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, Plasma
  • Sample volume: 20 µl
  • Incubation time: 20 min
  • Measuring range: 0 – 600 U/ml
  
 
  DiaSorin Liaison EA IgG  
 
  • 2-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, Plasma
  • Sample volume: 20 µl
  • Incubation time: 20 min .
  • Measuring range: 0 – 150 U/ml
  
 
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Product code Product name Method Kit Size Sample Type
310500 Liaison EBV IgM 2-step immunoluminometric sandwich assay 100 test kit Serum, Plasma
310510 Liaison VCA IgG 2-step immunoluminometric sandwich assay 100 test kit Serum, Plasma
310520 Liaison EBNA IgG 2-step immunoluminometric sandwich assay 100 test kit Serum, Plasma
310540 Liaison EA IgG 2-step immunoluminometric sandwich assay 100 test kit Serum, Plasma
P001606 ETI-EBV-M reverse (VCA IgM) ELISA 96 wells Serum, Plasma
P001601 ETI-VCA-G (VCA IgG) ELISA 96 wells Serum, Plasma
P001607 ETI-EBNA-G (EBNA-1 IgG) ELISA 96 wells Serum, Plasma
P002093 ETI-EA-G (EA(D) IgG) ELISA 96 wells Serum, Plasma
 
 
   
 

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