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Low levels of 1, 25(OH)2 Vitamin D can be seen in kidney disease and are one of
the earliest changes to occur in persons with early kidney failure. High levels
of 1, 25(OH)2 Vitamin D may occur when there is excess parathyroid hormone or
when there are diseases, such as sarcoidosis or some lymphomas, that can make 1,
25(OH)2 Vitamin D outside of the kidneys. |
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Product code |
Product name |
Method |
Kit Size |
Sample Type |
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65100E |
1, 25(OH)2 Vitamin D |
RIA |
100 tubes |
Serum, EDTA-Plasma |
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Liaison 1, 25(OH)2 Vitamin D |
Fully automated LIAISON |
Under Development |
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Vitamin D3 (cholecalciferol) is synthesized in the skin from
7-dehydrocholesterol in response to sunlight. Cholecalciferol is converted in
the liver to 25-hydroxyvitamin D, which is the most abundant form in serum. 25
OH Vitamin D concentrations in serum or plasma are considered to be the best
indicator of vitamin D nutritional status and are routinely measured. |
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Vitamin D is well-recognized in the maintenance of bone homeostasis, and vitamin
D sufficiency has been linked to decreased risk of many cancers, diabetes
mellitus, multiple sclerosis, cardiovascular disease, tuberculosis, and
recurrent falls in the elderly. |
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Vitamin D3 (cholecalciferol) is the form of vitamin D that occurs naturally in
humans, but vitamin D deficiency is commonly treated with vitamin D2
(ergocalciferol) and D3 (cholecalciferol). Fortified foods or supplements may
contain either form, thus it is important that an assay measure the active D2
and D3 forms of 25 OH Vitamin D equally, but not the inactive 3-epi form. |
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DiaSorin Liaison 25 OH Vitamin D Total |
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- Competitive immunoluminometric direct assay using directly coated magnetic
microparticles
- Sample matrix: Serum, EDTA Plasma, Lithium heparin plasma
- Sample volume: 25 µl
- Incubation time: 20 min
- Measuring range: 4.0 – 150 ng/ml
- Detection Limit: 4.0 ng/ml
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Product code |
Product name |
Method |
Kit Size |
Sample Type |
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310600 |
Liaison 25 OH Vitamin D Total |
Competitve immunoluminometric direct assay |
100 test kit |
Serum, Plasma |
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68100E |
25-hydroxyvitamin D |
RIA |
100 tubes |
Serum, Plasma |
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The maintenance of proper calcium concentrations in cells and extracellular
fluids is essential for fundamental biological processes. Parathyroid hormone
(PTH) is one of the important regulators of calcium homeostasis. |
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The measurement of PTH is used in conjunction with calcium determinations to
assess disorders in calcium metabolism. The measurement of PTH has proven to be
difficult due to the heterogeneity of peptides that occur in both the gland and
circulation. When using PTH concentrations to evaluate patients, the measurement
of intact PTH correlates best with their state of calcium metabolism. |
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DiaSorin Liaison Intact PTH |
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- Direct, 2-site, sandwich type immunoluminometric assay using directly coated
magnetic microparticles Sample matrix: Serum, Plasma
- Sample volume: 200 µl
- Incubation time: 20 minutes
- Measuring range: 2.1 – 2000 pg/ml
- Detection Limit: 1.0 pg/ml
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Product code |
Product name |
Method |
Kit Size |
Sample Type |
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310910 |
Liaison N-tact PTH |
Direct, 2-site, immunoluminometric assay |
100 test kit |
Serum, Plasma |
13065
13130 |
C-terminal PTH |
RIA |
65 tubes / 130 tubes |
Serum, EDTA-Plasma |
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26100 |
N-tact PTH SP |
RIA |
100 beads |
Serum, EDTA-Plasma |
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Osteocalcin, a vitamin K-dependent protein, has been described as one of the
most abundant non-collagenous proteins in bone. Osteocalcin may account for up
to 3% of total bone protein and contains three amino acid residues of gamma
carboxyglutamic acid (GLA), hence the designation, bone GLA protein, BGP, or
Osteocalcin, is found only in bone tissue and is produced by the osteoblast. It
is believed to play a role in the mineralization process and may be under the
influence of the other calcium-regulating hormones: calcitonin, parathyroid
hormone and vitamin D. Because the levels of Osteocalcin are a direct reflection
of bone turnover, its measurement closely correlates with the actual status of
bone metabolism in the patient. While such measurements as alkaline phosphatase
and hydroxyproline have been widely used as biochemical markers for bone
metabolism, there have been significant limitations in their usefulness as
specific markers for bone disease. Generally, Osteocalcin correlates with
alkaline phosphatase; however, because the concentration of alkaline phosphatase
is contributed by the other areas of the body, (i.e. liver, gastro-intestinal
tract, placenta and tumors) it is not specific for bone turnover. Increased
levels of Osteocalcin are found in bone diseases characterized by increased bone
turnover. Osteocalcin has been found to be elevated in the following disorders:
Paget’s disease of the bone, cancer accompanied by bone metastases, primary
hyperparathyroidism and renal osteodystrophy. Osteocalcin has the important
advantage of being a specific marker for bone disease. More importantly,
Osteocalcin levels may serve as a useful index in evaluating the therapeutic
management of the patient. |
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BRAHMS Kryptor Osteocalcin |
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- TRACE technology (Time resolved amplified cryptate emission)
- Sample matrix: Serum, plasma
- Diluent included in kit
- Sample volume: 8 µl
- Incubation time: 14 min
- Direct measuring range: 0 – 270 ng/ml
- Range with automated dilution: 0 – 2700 ng/ml
- Detection Limit: 0.2 ng/ml
- Intra – assay and Inter-assay coefficients of variation are 1.1 – 4.6 % and 4.3
– 5.5 % , respectively
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DiaSorin Liaison Osteocalcin |
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- Direct, two-site, sandwich type immunoluminometric assay using directly coated
magnetic microparticle
- Sample matrix: Serum
- Sample volume: 25 µl
- Incubation time: 10 minutes
- Measuring range: 0.3 – 300 ng/ml
- Detection Limit: 0.3 ng/ml
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Product code |
Product name |
Method |
Kit Size |
Sample Type |
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310950 |
Liaison Osteocalcin |
Direct, two-site, sandwich immunoluminometric assay |
100 test kit |
Serum |
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835.050 |
BRAHMS Osteocalcin |
KRYPTOR TRACE Technology |
50 test kit |
Serum, plasma |
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32300 |
N-tact Osteo SP (Osteocalcin) |
RIA |
100 beads |
Serum |
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Bone Alkaline Phosphatase (BAP) is a serum marker for osteoblastic bone
formation. The concentration of BAP in human serum correlates with the rate of
skeletal osteoblastic bone formation. Measurement of BAP is useful in diagnosing
Paget’s disease and osteoporosis, and in monitoring the response to
antiresorptive therapy in these patients.
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DiaSorin Liaison BAP Ostase |
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- Direct, two-site, sandwich type immunoluminometric assay using directly coated
magnetic microparticle
- Sample matrix: Serum
- Sample volume: 50 µl
- Incubation time: 30 minutes
- Measuring range: 0 – 120 µg/l
- Detection Limit: 0.1 µg/l
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Product code |
Product name |
Method |
Kit Size |
Sample Type |
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310970 |
Liaison BAP Ostase |
Direct, two-site, sandwich immunoluminometric assay |
100 test kit |
Serum |
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