Client SurveyCape Town
   
      
  Adrenal Function  
   
   
     
  ACTH  
     
  Adrenocorticotropic hormone or corticotrophin (ACTH) is a 39 amino acid polypeptide secreted by the anterior pituitary gland. It stimulates the adrenal cortex to secrete glucocorticoids like Cortisol and exerts some control over secretion of Aldosterone, the other major steroid hormone secreted by the adrenal cortex. Within the pituitary gland, ACTH is produced in a process that also generates several other hormones. The precursor of ACTH is a large protein called propiomelanocortin (POMC) synthesized and proteolytically cleaved into fragments that include also lipotropin (precursor of beta-endorphin and met-encephalin) and melanocyte-stimulating hormone (MSH). Plasma ACTH determination is useful in diagnosing disorders of the hypothalamic-pituitary-adrenal system.  
     
  DiaSorin Liaison ACTH  
 
  • 1-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Frozen EDTA plasma
  • Sample volume: 150 µl
  • Incubation time: 20 min
  • Measuring range: 1.6 – 1500 pg/ml
  • Detection Limit: 1.6 pg/ml
  
 
Product code Product name Method Kit Size Sample TypSample Type
313221 Liaison ACTH 1-step immunoluminometric sandwich assay 100 test kit Frozen EDTA plasma
24130 DiaSorin ACTH RIA 130 Tubes EDTA Plasma
27065
27130 		DiaSorin ACTH IRMA RIA 65 Beads /130 Beads EDTA Plasma
 
     
 
Back To Top      
  Cortisol  
     
  Changed patterns of serum Cortisol levels have been observed in connection with abnormal ACTH levels, clinical depression, psychological stress, and such physiological stressors as hypoglycemia, illness, fever, trauma, surgery, fear, pain, physical exertion or extremes of temperature.  
     
  A Cortisol test may be ordered when a patient has symptoms that suggest Cushing’s syndrome (obesity, muscle wasting, and muscle weakness) or Addison’s disease (weakness, fatigue, increased pigmentation, among others).  
     
  DiaSorin Liaison Cortisol  
 
  • 2-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, Plasma, Urine
  • Sample volume: 50 µl
  • Incubation time: 10 minutes
  • Measuring range: 0.15 - 80 µg/dl.
  • Detection Limit: < 0.15 µg/dl
  
 
Product code Product name Method Kit Size Sample Type
313261 Liaison Cortisol Competitive immunoluminometric sandwich assay 100 test kit Serum, Plasma, Urine
CA1529E
CA1549E 		GammaCoat Cortisol ROA Coated Tubes 100 Tubes / 500 Tubes Serum, Plasma, Urine, Saliva
 
 
Back To Top      
  DHEAs  
     
  The main indications for DHEAs assay are for the diagnosis of endocrine pathologies, especially those of adrenal origin:  
  Evaluation of puberty: DHEAs levels are low in case of delayed puberty and high in case of precocious puberty.  
  Evaluation of adrenal function: DHEAs levels are low in primary and secondary hypoadrenalism; conversely, DHEAs is the only androgen present in abnormally high concentrations in hirsute amenorrhoeic women in whom the syndrome is of adrenal origin, and in patients affected by congenital adrenal hyperplasia (CAH). DHEAs assay is suggested during dexamethasone suppression tests, because DHEAs levels remain low for 30-90 days.  
     
  Most patients affected by Cushing's disease (pituitary etiology) have moderately elevated levels of DHEAs. High levels of DHEAs are often found in polycystic ovary syndrome, showing that adrenal hyperandrogenism is fairly typical of this syndrome. Very high levels of DHEAs in women are suggestive of a hormone-secreting adrenal tumor. Since DHEAs levels reflect adrenal androgen production, the measurement of serum concentrations serve as an early marker for the onset of adrenarche. Serum DHEAs measurements are most commonly employed in the differential diagnosis of a virilized patient. Virilization is due to high levels of androgens (testosterone), which can induce balding (alopecia), amenorrhea and abnormal hair growth (hirsutism). Virilizing tumors of the ovary are associated with marked increases in serum testosterone, but near normal DHEAs levels. Virilizing tumors of the adrenals secrete very large amounts of potent androgens as well as DHEAs.  
     
  DiaSorin Liaison DHEAs  
 
  • Competitive 1-step immunoluminometric sandwich assay using directly coated magnetic microparticles
  • Sample matrix: Serum, plasma
  • Sample volume: 10 µl
  • Incubation time: 21 minutes
  • Measuring range: 1.0 – 750 mg/dl
  • Detection Limit: 0.4 mg/dl
  
 
PProduct code Product name Method Kit Size Sample Type
310430 Liaison DHEAs Competitive 1-step immunoluminometric sandwich assay 100 test kit Serum, plasma
 
     
Back To Top    
 
 

LINKS

http://www.diasorin.com/

  
 
Back To Top      
  Home | About us | Contact
Copyright © Humor Diagnostica